If you use Determination runes on defense tanks, look for speed, %Defense, %Crit damage and primary stats as substats in all runes.
Since Determination rune set effect works on all allies, you should focus on your main purpose as a team: having a good Defense is a great feature to have in context such as Arena Defense, Guild Battle Defense, Live Arena and Raid Battle. Fight rune set effect works good if you have defense based damage dealers, defense tanks, revivers or support on your team, such as:
You can equip this rune set on every whatever monster you may like, even if it’s not a defense tank, since the effect will be added to all the monsters on your team.